Beneficial Effects of Ozone

The beneficial effects of ozone on health are the following:

  • It regulates the cellular oxidative stress factors contributing to strengthen antioxidant and anti-free radical fighting.
  • Causes an increase of metabolism of O2 in the case of tissue hypoxia.
  • Modulates autoimmune activity. Ozone can trigger the production of cytokines (interferon, tumor necrosis factor, interleukins, etc.) from monocytes and lymphocytes in the peripheral blood. These blood cells are captured by activated lymphoid tissue (spleen, bone marrow and lymph nodes) where the release of cytokines produce a modulation of the immune system. These cellular interactions produced by ozone are very similar to the physiological processes that occur in the body to maintain the immune system in an active state. That is why no adverse effects are observed with the application of this therapy.
  • It has a high bactericidal and germicidal power. The germicidal action of ozone is based on the formation of toxic molecules such as hydrogen peroxide, and highly toxic free radicals (as superoxide), which are especially toxic to anaerobic organisms, since they lack endogenous enzyme systems capable of breaking down these products and dispose of the body.
  • It is an activator circulation. After ozone treatment, the blood improves its ability to circulate through closer microcapillaries, thus improving the microcirculation by platelet disaggregation.
  • In addition, erythrocytes are broken down and softened in a better position to absorb and transfer oxygen, among other factors, due to the increased surface contact and deflection free. Arterial oxygen pressure increases, and venous oxygen pressure decreases, thus improving cellular oxygenation. There is an increase of 2.3 DPG (Diphospho glycerol), which facilitates the transfer of oxygen trapped in the oxyhemoglobin in red blood cells.
  • It is an analgesic and anti-inflammatory.
  • It is a stimulator of tissue regeneration.

All these properties make ozone a valuable therapy specially in:

  • Wounds and ulcers.
  • All the healing process.
  • Burns and abscesses.
  • Infected ulcers of torpid evolution or difficult to heal, such as diabetic foot or diabetic ulcers.
  • Viral pathologies: hepatitis or herpes.
  • Joint inflammations in orthopedics and rheumatology.
  • Cellulite.
  • Location of stress.
  • Osteoporosis.
  • Gynecology: in vulvovaginitis and vaginosis fungal or bacterial origin.
  • Geriatrics: to increase the quality of life and to improve cerebral oxygenation in symptoms such as memory loss, difficulty circulation in legs, fatigue, etc.
  • It helps in cancer treatment.
  • General activator of the immune system
  • Resolute in herniated discs.
  • Finally, recent studies have found ozone useful in the treatment of glaucoma and macular ophthalmology.

1) Scientific evidences of ozonetherapy

The ozonetherapy is characterized by the simplicity of its implementation, high effectiveness, good tolerance, and with virtually no side effects. For a long time in the past the ozone application in medical practice was not accepted by unfounded ideas on toxicity in relation to the high concentrations used in the industry. As any other means of healing, ozonetherapy depends on the dose.
It is important to know that in clinical practice ozone concentrations are lower than the toxic substances by several orders of magnitude. In the diapason of these concentrations ozone acts as a therapeutic and shows immuno-modulatory, anti-inflammatory, antibacterial, antiviral, fungicidal, analgesic and others properties. The number of scientific societies and clinical research, including meta-analysis assessments is increasing more and more. Simultaneously efforts to regularize the practice of ozonetherapy are being strengthened.

To expand on the scientific evidence supporting the clinical use of ozone therapy see:

Schwartz, A, Martinez-Sanchez, G. (2012). Ozonetherapy and its scientific support. Spanish Journal of Ozone Therapy. Vol. 2, No 1, p. 199-232.

2) Methods for practicing the ozonetherapy

The success of ozonetherapy is dependent on several factors, which include among them, the knowledge of the professional that practice it, the doses, the selection of routes of administration and the protocol of treatment.
For more information on this subject see the “Madrid Declaration on ozone therapy” approved on June 4, 2010 in the “International Meeting of Schools of Ozonetherapy” organized by AEPROMO at the Royal National Academy of Medicine (Madrid). The Declaration has been signed by 26 national and international associations of Ozonetherapy and it has been translated into 10 languages.

If you are a healthcare professional and need detailed information on procedures and techniques recommended for the practice of ozonetherapy, please consult the book: Adriana Schwartz et al., “Guide for the medical use of ozone – Therapeutic foundations and indications”, AEPROMO, 2011, 315 p. + XVIII + 11 p. color plates. ISBN: 978-84-615-2244-6. Written in Spanish.

3) Regularization of the ozonetherapy

Out of 17 Spanish communities (states) in 14 the authorities have listed the requirements that outpatient private centers must fulfill to perform ozonetherapy. The first community to regularize it was Madrid on March 9, 2009. In the communities where the requirements have not yet been established, the practice is widely tolerated by the health authorities.
For more information on this point, please refer to “news” of the following dates: March 9, 2009, March 2, 2010, May 31, 2010, September 17, 2010, December 11, 2010, and April 20 2011.

For a deeper understanding about the legal status of the ozonetherapy in Spain and other countries please read: Schwartz, Adriana; Quintero, Roberto (2012). Ozone and legislation. Analysis for regularization. Spanish Journal of Ozone Therapy. Vol. 2, No 1, p. 51-90.


This content is also available in: Spanish

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